TABLE 2.
Simple allometric scaling data for volume of distribution (Vz) of antimalarial drugs in healthy mammals
| Drug | Route of administrationa | No. of speciesb | r2 | Allometric exponent (95% CI) | Allometric coefficient | References |
|---|---|---|---|---|---|---|
| Artesunate | IV | 4 (r, d, p, h) | 0.69 | 0.54 (0.22–0.85) | 3.2 | 55, 58–62 |
| Dihydroartemisinin (from IV artesunate) | IV | 4 (r, d, p, h) | 0.99 | 0.86 (0.78–0.94) | 4.2 | 55, 58–63 |
| Artemether | IM | 3 (r, d, h) | 0.99 | 0.93 (0.82–1.05) | 12.4 | 59, 64–66 |
| Artemether | IM or IV | 4 (r, rb, d, h) | 0.96 | 1.06 (0.75–1.38) | 6.7 | 59, 64–67 |
| Clindamycin | IV | 3 (d, r, h) | 0.98 | 0.81 (0.72–0.91) | 2.5 | 80–86 |
| Piperaquine | Oral | 3 (m, r, h) | 0.94 | 1.16 (0.87–1.45) | 280 | 88–92 |
| Mefloquine | Oral | 3 (m, r, h) | 0.91 | 0.78 (0.66–0.90) | 39.8 | 93–110 |
| Quinine | IV | 4 (r, rb, d, h) | 0.92 | 0.88 (0.74–1.01) | 4.61 | 111–124 |
a
IV, intravenous; IM, intramuscular.
b
Species: m, mouse; r, rat; d, dog; p, pig; rb, rabbit; h, human.