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. 2014 Oct;58(10):5954–5963. doi: 10.1128/AAC.02781-14

FIG 8.

FIG 8

Compartmentalized killing describes the mechanism of synergy between IFN-γ and ceftazidime. We propose that during the macrophage infection assay, there is a dynamic exchange between bacteria in the intracellular and extracellular compartments. Therefore, it is only with IFN-γ control of intracellular spread and replication, combined with ceftazidime control of extracellular bacterial burden, that synergy is achieved with low bacterial burden in the system as a whole.