FIG 6.
Superposition among representative structures of AcrB in complex with MBX2319 (gray sticks in all panels), D13-9001 (A) (red), NMP (B) (green), PAβN (C) (yellow), DOX in complex with AcrBF610A (D) (violet), and MIN (E) (magenta). The G-loop tip is shown in ribbons (gray in free AcrB and colored like the ligands in complexes), while the residues of the hydrophobic trap within 3.5 Å of the ligands are shown by solid spheres. The two residues of the gate to the TolC docking domain (Q124 and Y758) are shown by blue spheres.