| HU 4 gr/D | |||||
| Diagn. | Mean age | # cases | Start trim. | Additional Drugs | Compl child (#w) |
|---|---|---|---|---|---|
| CML Chronic phase | 27 | 2 | All trimesters | None | All: bleeding, ARDS, Death |
| III | III: nihil | ||||
| Alfa-INF | |||||
| CML Chronic phase | 17 | I | abdominal shield measured fetal dose | - Nihil | |
| 26 | II | - Nihil | |||
| 5 | III | - Nihil | |||
| Imatinib 400 mg/D (Standard therapy) | |||||
| CML Chronic Phase | 32,8 | 3 | I | None | - Twins: a) nihil b) IUGD+death |
| Pyloorstenosis | |||||
| 1 | II | None | - Nihil | ||
| NA | 90 | All trimesters | - 63 healthy children (50%) | ||
| - 18 spontaneous abortions | |||||
| - 8 live births, 1 stillbirth with: cleft palate, polydactyly, meningocoele, premature closure skull sutures, scoliosis, exomphalos (33), hydrocephalus, hypospadias (23), pyloric stenosis, hypoplastic lungs, hemivertebrae, right shoulder anomaly, right renal agenesis (23) | |||||
| Busulfan + Radiotherapy | |||||
| CML Acute/ blastic Phase | NA | 13 | All trimesters | 6-mercaptopurine, alfa-INF, hydroxyurea | - 1 child with thrombocytopenia |
| - Others: nihil | |||||
Chronic leukemia – (Ali et al., 2005; Baer et al., 1992; Buykbayrak et al., 2008; Celiloglu et al., 2000; Dilet et al., 2006; Fadilah et al., 2002; Heartin et al., 2004; Meera et al., 2008; Mesquita et al., 2005; Pye et al., 2008).