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. 2014 Oct 7;5:225. doi: 10.3389/fphar.2014.00225

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Copyright © 2014 Cooper, Kliwinski, Perkinson, Ragwan, Mabus, Powers, Dorai, Giles-Komar and Hornby.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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The effect of pH (pH 6.0, 7.4, and 8.0.) of high and low FcRn-affinity IgG variants on serum uptake: Serum levels (ng/mL) at 90 min after administration of N434A tended to be higher following intra-duodenal administration (0.01 mg/kg) in suckling rat pups (n = 6). There was no difference in the serum levels of H435A administered in different pH conditions. One-way ANOVA Statistical tests carried out compared to N434A pH 6.0.