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Affinities and off-rates of IgG1 variants to FcRn.
| Affinity to rat FcRn (nM) |
pH shift (6–7.4) |
||
|---|---|---|---|
| IgG1 variant | pH 6.0 | pH 7.4 | rFcRn off-rate 1/s (s) |
| WT | 169 ± 8.8 | – | 0.07 ± 0.0004 |
| N434A | 77 ± 0.2 | – | 0.09 ± 0.001 (11 s) |
| N434Y | 27 ± 3.6 | 1240 | 0.02 ± 0.0008 (50 s) |
| H435A | – | – | – |
