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. 2014 Oct 6;55(10):6194–6203. doi: 10.1167/iovs.14-14841

Table 3.

Top10 SNPs From Each Analysis, Adjusted for Significant Covariates

C H R
SNP
BP
Gene
A1
Analysis 1: Any ROP vs. No ROP
Analysis 2: Severe ROP vs. Nonsevere ROP
Analysis 3: Severe ROP vs. Nonsevere ROP or No ROP
NIND
BETA
P
EMP1
NIND
BETA
P
EMP1
NIND
BETA
P
EMP1
1 rs9332681 169555791 F5 A 747 −0.202 0.0004 0.0008 510 0.082 0.2407 0.2386 747 0.001 0.9793 0.9789
1 rs379489 196693451 CFH T 816 −0.021 0.3926 0.4127 561 0.087 0.001 0.0009 816 0.055 0.0036 0.0038
1 rs395544 196698272 CFH A 817 −0.021 0.403 0.4193 561 0.085 0.0014 0.0015 817 0.053 0.0048 0.0054
1 rs11587174 197012491 F13B A 780 −0.181 0.0003 0.0006 538 0.085 0.1637 0.1639 780 0.007 0.8549 0.8561
2 rs1467199 191880502 STAT1 C 817 −0.086 0.0009 0.0017 561 0.022 0.454 0.4545 817 −0.004 0.8218 0.8208
5 rs34417936 55248135 IL T 798 −0.155 0.0006 0.0011 549 0.03 0.5634 0.5675 798 −0.015 0.6599 0.6632
7 rs2299386 103419656 RELN A 815 0.05 0.0379 0.0451 561 0.067 0.0078 0.0076 815 0.058 0.0015 0.0016
7 rs10251365 103420619 RELN A 817 −0.013 0.5943 0.6112 561 −0.086 0.0013 0.0014 817 −0.062 0.0012 0.001
8 rs16879811 32573039 NRG1 A 817 0.014 0.5809 0.599 561 0.095 0.0005 0.0008 817 0.07 0.0004 0.0004
8 rs16879814 32573583 NRG1 G 817 0.02 0.4471 0.4658 561 0.096 0.0005 0.0006 817 0.071 0.0003 0.0003
11 rs2353512 27679662 BDNF-AS A 795 −0.19 0.0007 0.0012 550 0.1 0.142 0.1451 795 0.013 0.7674 0.7686
11 rs7127507 27714884 BDNF G 817 0.017 0.4644 0.4829 561 0.086 0.0004 0.0004 817 0.063 0.0003 0.0002
11 rs2049046 27723775 BDNF A 817 0.028 0.2346 0.2482 561 0.097 6.26E-05 6.00E-05 817 0.074 2.43E-05 3.00E-05
11 rs7934165 27731983 BDNF C 816 0.023 0.3002 0.3139 560 0.1 2.47E-05 3.00E-05 816 0.075 1.25E-05 2.00E-05
11 rs12281784 46908250 LRP4 A 817 −0.095 0.0003 0.0005 561 0.067 0.0078 0.0076 817 −0.012 0.5393 0.5422
12 rs9989002 102850223 IGF1 T 808 −0.02 0.7562 0.7638 554 0.244 0.0006 0.0009 808 0.158 0.0015 0.0022
13 rs11620315 28997886 FLT1 C 817 0.13 0.0013 0.0018 561 −0.004 0.914 0.9162 817 0.024 0.432 0.4467
15 rs1319859 99230263 IGF1R A 814 0.072 0.0008 0.0013 559 0.015 0.502 0.5032 814 0.026 0.1134 0.1155
15 rs884636 99513784 PGPEP1L A 814 −0.383 0.001 0.0015 560 −0.216 0.2416 0.2562 814 −0.15 0.0932 0.1003
16 rs7204874 27303287 NSMC E1|IL4 R A 817 0.041 0.2656 0.2814 561 0.114 0.0033 0.0034 817 0.088 0.0016 0.0014
16 rs2057768 27322095 IL4R T 816 −0.016 0.5255 0.5422 561 −0.092 0.0007 0.0007 816 −0.068 0.0005 0.0007
18 rs1551005 29171690 TTR C 808 −0.204 0.0009 0.0014 556 0.081 0.2873 0.2906 808 −0.002 0.961 0.9603

CHR, chromosome; BP, base pair location; A1, minor allele; NIND, number of nonmissing individuals in analysis; BETA, regression coefficient; EMP1, point-wise empirical P value.