Table 3.
C H R |
SNP |
BP |
Gene |
A1 |
Analysis 1: Any ROP vs. No ROP |
Analysis 2: Severe ROP vs. Nonsevere ROP |
Analysis 3: Severe ROP vs. Nonsevere ROP or No ROP |
|||||||||
NIND |
BETA |
P |
EMP1 |
NIND |
BETA |
P |
EMP1 |
NIND |
BETA |
P |
EMP1 |
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1 | rs9332681 | 169555791 | F5 | A | 747 | −0.202 | 0.0004 | 0.0008 | 510 | 0.082 | 0.2407 | 0.2386 | 747 | 0.001 | 0.9793 | 0.9789 |
1 | rs379489 | 196693451 | CFH | T | 816 | −0.021 | 0.3926 | 0.4127 | 561 | 0.087 | 0.001 | 0.0009 | 816 | 0.055 | 0.0036 | 0.0038 |
1 | rs395544 | 196698272 | CFH | A | 817 | −0.021 | 0.403 | 0.4193 | 561 | 0.085 | 0.0014 | 0.0015 | 817 | 0.053 | 0.0048 | 0.0054 |
1 | rs11587174 | 197012491 | F13B | A | 780 | −0.181 | 0.0003 | 0.0006 | 538 | 0.085 | 0.1637 | 0.1639 | 780 | 0.007 | 0.8549 | 0.8561 |
2 | rs1467199 | 191880502 | STAT1 | C | 817 | −0.086 | 0.0009 | 0.0017 | 561 | 0.022 | 0.454 | 0.4545 | 817 | −0.004 | 0.8218 | 0.8208 |
5 | rs34417936 | 55248135 | IL | T | 798 | −0.155 | 0.0006 | 0.0011 | 549 | 0.03 | 0.5634 | 0.5675 | 798 | −0.015 | 0.6599 | 0.6632 |
7 | rs2299386 | 103419656 | RELN | A | 815 | 0.05 | 0.0379 | 0.0451 | 561 | 0.067 | 0.0078 | 0.0076 | 815 | 0.058 | 0.0015 | 0.0016 |
7 | rs10251365 | 103420619 | RELN | A | 817 | −0.013 | 0.5943 | 0.6112 | 561 | −0.086 | 0.0013 | 0.0014 | 817 | −0.062 | 0.0012 | 0.001 |
8 | rs16879811 | 32573039 | NRG1 | A | 817 | 0.014 | 0.5809 | 0.599 | 561 | 0.095 | 0.0005 | 0.0008 | 817 | 0.07 | 0.0004 | 0.0004 |
8 | rs16879814 | 32573583 | NRG1 | G | 817 | 0.02 | 0.4471 | 0.4658 | 561 | 0.096 | 0.0005 | 0.0006 | 817 | 0.071 | 0.0003 | 0.0003 |
11 | rs2353512 | 27679662 | BDNF-AS | A | 795 | −0.19 | 0.0007 | 0.0012 | 550 | 0.1 | 0.142 | 0.1451 | 795 | 0.013 | 0.7674 | 0.7686 |
11 | rs7127507 | 27714884 | BDNF | G | 817 | 0.017 | 0.4644 | 0.4829 | 561 | 0.086 | 0.0004 | 0.0004 | 817 | 0.063 | 0.0003 | 0.0002 |
11 | rs2049046 | 27723775 | BDNF | A | 817 | 0.028 | 0.2346 | 0.2482 | 561 | 0.097 | 6.26E-05 | 6.00E-05 | 817 | 0.074 | 2.43E-05 | 3.00E-05 |
11 | rs7934165 | 27731983 | BDNF | C | 816 | 0.023 | 0.3002 | 0.3139 | 560 | 0.1 | 2.47E-05 | 3.00E-05 | 816 | 0.075 | 1.25E-05 | 2.00E-05 |
11 | rs12281784 | 46908250 | LRP4 | A | 817 | −0.095 | 0.0003 | 0.0005 | 561 | 0.067 | 0.0078 | 0.0076 | 817 | −0.012 | 0.5393 | 0.5422 |
12 | rs9989002 | 102850223 | IGF1 | T | 808 | −0.02 | 0.7562 | 0.7638 | 554 | 0.244 | 0.0006 | 0.0009 | 808 | 0.158 | 0.0015 | 0.0022 |
13 | rs11620315 | 28997886 | FLT1 | C | 817 | 0.13 | 0.0013 | 0.0018 | 561 | −0.004 | 0.914 | 0.9162 | 817 | 0.024 | 0.432 | 0.4467 |
15 | rs1319859 | 99230263 | IGF1R | A | 814 | 0.072 | 0.0008 | 0.0013 | 559 | 0.015 | 0.502 | 0.5032 | 814 | 0.026 | 0.1134 | 0.1155 |
15 | rs884636 | 99513784 | PGPEP1L | A | 814 | −0.383 | 0.001 | 0.0015 | 560 | −0.216 | 0.2416 | 0.2562 | 814 | −0.15 | 0.0932 | 0.1003 |
16 | rs7204874 | 27303287 | NSMC E1|IL4 R | A | 817 | 0.041 | 0.2656 | 0.2814 | 561 | 0.114 | 0.0033 | 0.0034 | 817 | 0.088 | 0.0016 | 0.0014 |
16 | rs2057768 | 27322095 | IL4R | T | 816 | −0.016 | 0.5255 | 0.5422 | 561 | −0.092 | 0.0007 | 0.0007 | 816 | −0.068 | 0.0005 | 0.0007 |
18 | rs1551005 | 29171690 | TTR | C | 808 | −0.204 | 0.0009 | 0.0014 | 556 | 0.081 | 0.2873 | 0.2906 | 808 | −0.002 | 0.961 | 0.9603 |
CHR, chromosome; BP, base pair location; A1, minor allele; NIND, number of nonmissing individuals in analysis; BETA, regression coefficient; EMP1, point-wise empirical P value.