Table 4.
Results of Meta-Analysis of Discovery and Replication Cohorts
|
Model |
SNP |
Gene |
Study Name |
Analysis 2, Adjusted |
Analysis 3, Adjusted |
||||
|
Odds Ratio (95% CI) |
Z
Value |
P
Value |
Odds Ratio (95% CI) |
Z
Value |
P
Value |
||||
| rs7934165, add | BDNF | Discovery - Unrelated | 2.0 (1.4–2.7) | 4.1 | 4.04E-05 | 2.3 (1.6–3.2) | 4.6 | 3.80E-06 | |
| rs7934165, add | BDNF | Discovery - Related | 1.0 (0.01–15.9) | 0.0 | 1.0000 | 142.4 (0.0–5070080.8) | 0.9 | 0.3537 | |
| rs7934165, add | BDNF | Replication - Unrelated | 0.9 (0.6–2.3) | −0.2 | 0.8450 | 1.1 (0.4–3.4) | 0.3 | 0.8021 | |
| Fixed | rs7934165, add | BDNF | 1.8 (1.3–2.4) | 3.8 | 0.0002 | 2.1 (1.5–3.0) | 4.5 | 6.80E-06 | |
| rs7934165, dom | BDNF | Discovery - Unrelated | 2.1 (1.2–3.8) | 2.5 | 0.0121 | 2.1 (1.1–3.9) | 2.5 | 0.0129 | |
| rs7934165, dom | BDNF | Replication - Unrelated | 0.6 (0.1–2.3) | −0.8 | 0.4373 | 0.6 (0.1–2.9) | −0.7 | 0.5068 | |
| Fixed | rs7934165, dom | BDNF | 1.7 (1.0–3.0) | 2.0 | 0.0431 | 1.8 (1.0–3.2) | 2.1 | 0.0359 | |
| rs7934165, rec | BDNF | Discovery - Unrelated | 2.7 (1.7–4.3) | 4.2 | 2.76E-05 | 3.6 (2.2–5.9) | 5.0 | 5.11E-07 | |
| rs7934165, rec | BDNF | Replication - Unrelated | 1.5 (0.3–6.5) | 0.5 | 0.6255 | 2.6(0.5–13.6) | 1.1 | 0.2670 | |
| Fixed | rs7934165, rec | BDNF | 2.6 (1.6–4.0) | 4.1 | 3.34E-05 | 3.5 (2.2–5.7) | 5.1 | 2.91E-07 | |
| rs2049046, add | BDNF | Discovery - Unrelated | 1.9 (1.4–2.7) | 3.9 | 1.06E-04 | 2.3 (1.6–3.3) | 4.5 | 6.33E-06 | |
| rs2049046, add | BDNF | Discovery - Related | 1.0 (0.1–15.9) | 0.0 | 1 | 142.4 (0.0–5070080.8) | 0.9 | 0.3537 | |
| rs2049046, add | BDNF | Replication - Unrelated | 0.9 (0.4–2.2) | −0.2 | 0.8404 | 0.9 (0.3–2.6) | −0.2 | 0.8534 | |
| Fixed | rs2049046, add | BDNF | 1.7 (1.3–2.4) | 3.5 | 0.0004 | 2.1 (1.5–2.9) | 4.3 | 2.13E-05 | |
| rs2049046, dom | BDNF | Discovery - Unrelated | 1.9 (1.1–3.4) | 2.2 | 0.0270 | 1.9 (1.1–3.5) | 2.2 | 0.0259 | |
| rs2049046, dom | BDNF | Replication - Unrelated | 0.5 (0.1–2.0) | −0.9 | 0.3469 | 0.4 (0.1–2.2) | −1.0 | 0.3092 | |
| Fixed | rs2049046, dom | BDNF | 1.6 (0.9–2.7) | 1.7 | 0.0926 | 1.6 (0.9–2.9) | 1.8 | 0.0779 | |
| rs2049046, rec | BDNF | Discovery - Unrelated | 2.7 (1.7–4.3) | 4.1 | 4.65E-05 | 3.8 (2.3–6.3) | 5.1 | 4.00E-07 | |
| rs2049046, rec | BDNF | Replication - Unrelated | 1.5 (0.4–5.9) | 0.6 | 0.5529 | 1.8 (0.4–8.8) | 0.7 | 0.4887 | |
| Fixed | rs2049046, rec | BDNF | 2.5 (1.6–3.9) | 4.0 | 5.30E-05 | 3.5 (2.2–5.7) | 5.0 | 4.65E-07 | |
Data not shown for analyses without informative observations. Analysis 2 (severe ROP versus nonsevere ROP) was adjusted for occurrence of seizures. Analysis 3 (severe ROP versus nonsevere or no ROP) was adjusted for occurrence of seizures and number of days of ventilation within 28 days. In analysis 3, under a recessive model, rs7934165 increased in associated significance with severe ROP in meta-analysis compared to the discovery cohort. Add, additive genetic model; dom, dominant genetic model; rec, recessive genetic model.