Table 2. Factors associated with changes in cognitive function scores during follow up.

	Univariate analysis		Multivariate analysis
	Correlation coefficient	P‐value	Standardized β coefficient (SE)	P‐value
ΔMMSE			r2 = 0.306, P = 0.001
Age	−0.309	0.011	−0.209 (0.078)	0.092
DBP at baseline	0.261	0.033	0.176 (0.052)	0.127
eGFR at baseline	0.260	0.034	0.130 (0.029)	0.306
Log IL‐6 at baseline	−0.254	0.040	−0.139 (1.406)	0.200
MMSE at baseline	−0.235	0.056	−0.367 (0.153)	0.002
HDL‐C at baseline	0.205	0.096	0.145 (0.026)	0.209
ΔWord recall (z‐score)			r2 = 0.297, P < 0.001
ΔLog ACR	−0.476	0.000	−0.427 (0.208)	0.000
Word recall at baseline	−0.292	0.016	−0.204 (0.102)	0.084
Education years	−0.207	0.093	0.110 (0.392)	0.323
Log TG at baseline	0.230	0.061	−0.045 (0.042)	0.698
ΔDSS test (z‐score)			r2 = 0.229, P = 0.009
Age	−0.305	0.014	−0.261 (0.013)	0.041
DBP at baseline	0.296	0.016	0.242 (0.009)	0.051
Average DBP during follow up	0.244	0.051	Not applied
FBG at baseline	−0.214	0.084	−0.272 (0.002)	0.026
Education years	0.207	0.093	−0.137 (0.030)	0.253
Log IL‐6 at baseline	−0.212	0.093	−0.053 (0.236)	0.682
ΔStroop test (z‐score)			r2 = 0.628, P < 0.001
Stroop score at baseline	−0.570	0.000	−0.632 (0.097)	0.000
Average DBP during follow up	0.402	0.001	0.252 (0.019)	0.021
HbA1c at baseline	−0.318	0.009	−0.175 (0.133)	0.046
Smoking	−0.250	0.043	−0.128 (0.272)	0.134
Average SBP during follow up	0.219	0.077	−0.046 (0.011)	0.658
DBP at baseline	0.208	0.094	Not applied

No smoking was 0, smoking was 1. Δ, change; ACR, albumin to creatinine ratio; DBP, diastolic blood pressure; DSS, Digit Symbol Substitution; eGFR, estimated glomerular filtration rate; FBG, fasting blood glucose; HbA1c, glycated hemoglobin; HDL‐C, high‐density lipoprotein cholesterol; IL, interleukin; MMSE, Mini‐Mental State Examination; SBP, systolic blood pressure; SE, standard error; TG, triglycerides.