Table 2.
Most representative meta-analyses on the relationship between subclinical hypothyroidism and coronary heart disease.
Reference | Number of studies | Study population (subjects with sHT) | Age | Endpoint | Outcome |
|
---|---|---|---|---|---|---|
Whole cohort | Subjects older than 65 years | |||||
Singh et al. (97) | 6 | 11,495 (935) | 58–75 | CHD events | RR 1.18 (CI 1.02–1.37) | NA |
CVM | RR 1.11 (CI 0.99–1.25) | |||||
Haentjens et al. (102) | 9 | 13,329 (290) | 50–85 | CVM | HR 1.22 (95% CI 0.96–1.57) | NA |
Ochs et al. (66) | 10 | 14,449 (1491) | 46–85 | CHD events | HR 1.20 (95% CI 0.97–1.49) | <80 and HR 1.06 (95% CI 0.91–1.24) |
>80 and HR 0.47 (95% CI 0.11–1.90) | ||||||
CVM | HR 1.18 (95% CI 0.98–1.42) | <80 and HR 1.12 (95% CI 0.99–1.28) | ||||
>80 and HR 0.55 (95% CI 0.24–1.25) | ||||||
Razvi et al. (95) | 15 | 29,022 (2531) | 42–85 | CHD events | HR 1.27 (95% CI 0.95–1.22) | HR 1.02 (95% CI 0.85–1.22) |
CVM | HR 1.09 (95% CI 0.84–1.41) | HR 0.85 (95% CI 0.56–1.29) | ||||
Rodondi et al. (93) | 11 | 55,287 (3450) | 46–85 | CHD events | HR 1.18 (95% CI 0.99–1.42) | <80 and HR 1.20 (95% CI 0.95–1.51) |
>80 and HR 1.30 (95% CI 0.93–1.82) | ||||||
CVM | HR 1.09 (95% CI 0.96–1.24) | <80 and HR 1.32 (95% CI 1.08–1.62) | ||||
>80 and HR 1.01 (95% CI 0.62–1.63) |
sHT, subclinical hypothyroidism; CHD, coronary heart disease; CVM, cardiovascular mortality; HR, hazard ratio; NA, not available.