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. 2014 Oct 7;5:153. doi: 10.3389/fendo.2014.00153

Table 2.

Most representative meta-analyses on the relationship between subclinical hypothyroidism and coronary heart disease.

Reference Number of studies Study population (subjects with sHT) Age Endpoint Outcome
Whole cohort Subjects older than 65 years
Singh et al. (97) 6 11,495 (935) 58–75 CHD events RR 1.18 (CI 1.02–1.37) NA
CVM RR 1.11 (CI 0.99–1.25)
Haentjens et al. (102) 9 13,329 (290) 50–85 CVM HR 1.22 (95% CI 0.96–1.57) NA
Ochs et al. (66) 10 14,449 (1491) 46–85 CHD events HR 1.20 (95% CI 0.97–1.49) <80 and HR 1.06 (95% CI 0.91–1.24)
>80 and HR 0.47 (95% CI 0.11–1.90)
CVM HR 1.18 (95% CI 0.98–1.42) <80 and HR 1.12 (95% CI 0.99–1.28)
>80 and HR 0.55 (95% CI 0.24–1.25)
Razvi et al. (95) 15 29,022 (2531) 42–85 CHD events HR 1.27 (95% CI 0.95–1.22) HR 1.02 (95% CI 0.85–1.22)
CVM HR 1.09 (95% CI 0.84–1.41) HR 0.85 (95% CI 0.56–1.29)
Rodondi et al. (93) 11 55,287 (3450) 46–85 CHD events HR 1.18 (95% CI 0.99–1.42) <80 and HR 1.20 (95% CI 0.95–1.51)
>80 and HR 1.30 (95% CI 0.93–1.82)
CVM HR 1.09 (95% CI 0.96–1.24) <80 and HR 1.32 (95% CI 1.08–1.62)
>80 and HR 1.01 (95% CI 0.62–1.63)

sHT, subclinical hypothyroidism; CHD, coronary heart disease; CVM, cardiovascular mortality; HR, hazard ratio; NA, not available.