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. 2014 Sep;184(9):2403–2419. doi: 10.1016/j.ajpath.2014.05.024

Figure 5.

Figure 5

Focal lipid accumulation in the Cyp27a1−/−Cyp46a1−/− retina. Representative staining of the cross section through the area of pathology in the Cyp27a1−/−Cyp46a1−/− retina (A–C) and the corresponding region in the Cyp27a+/+Cyp46a1+/+ retina (K–M). N: Histological quantifications. Representative staining of the cross sections through the aortic root of the heart in the Cyp27a1−/−Cyp46a1−/− (J) and Cyp27a1+/+Cyp46a1+/+ (O) mice. Enlarged view of the boxed regions in A–C (F–H). TEM of the Cyp27a1−/−Cyp46a1−/− retina confirm lipid deposition inside and outside blood vessels (white and yellow arrows, respectively, in D), away from blood vessels (orange arrows, E), and in the RPE (magenta arrow, I). Scale bars: 100 μm (A–C, F–H, J, K–M, and O); 2 μm (D and E); 1 μm (I). INL, inner nuclear layer; ONL, outer nuclear layer; OPL, outer plexiform layer; PR, photoreceptor; RPE, retinal pigment epithelium.