Table 9.

Classification performance of the CTL vs. MCI, CTL vs. AD and MCI vs. AD models for the different normalizations of hippocampal data.

	Raw hippocampus volumes	Hippocampus/ICV	Residually corrected hippocampus volumes
AUC: CTL vs. MCIa	0.73 [0.69–0.77]	0.76 [0.72–0.80]	0.75 [0.70–0.79]
AUC: CTL vs. ADb	0.88 [0.84–0.91]	0.89 [0.85–0.92]	0.90 [0.87–0.93]
AUC: MCI vs. ADc	0.69 [0.64–0.74]	0.66 [0.62–0.71]	0.70 [0.65–0.75]

Data are presented as mean [95% confidence interval]. CTL, cognitive normal; MCI, mild cognitive impairment; AD, Alzheimer's disease.

^aIn the CTL vs. MCI contrast, the area under the receiver operating curve (AUC) obtained from using hippocampus/ICV volumes was significantly greater comparing to the AUC obtained from both raw (p = 0.048) and residual (p = 0.037) hippocampus volumes.

^bIn the CTL vs. AD contrast, the AUC obtained from using residually corrected hippocampal volumes was significantly greater comparing to the AUC obtained from raw hippocampal volumes (p = 0.001).

^cIn the MCI vs. AD contrast, AUC obtained from using residually corrected hippocampal volumes was significantly greater comparing to the AUC obtained from hippocampus/ICV volumes (p < 0.001).