Table 3.
Genotype constellations of avian RVAs, RVAs from exotic animals, and unusual RVA strains detected in livestock and companion animals with those of selected common bovine, canine/feline, equine, human and porcine RVA strains
| Strain | Genotypes | ||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| VP7 | VP4 | VP6 | VP1 | VP2 | VP3 | NSP1 | NSP2 | NSP3 | NSP4 | NSP5 | |
| Humans | |||||||||||
| RVA/Human-tc/USA/Wa/1974/G1P1A[8] | G1 | P[8] | I1 | R1 | C1 | M1 | A1 | N1 | T1 | E1 | H1 |
| RVA/Human-tc/USA/DS-1/1976/G2P1B[4] | G2 | P[4] | I2 | R2 | C2 | M2 | A2 | N2 | T2 | E2 | H2 |
| RVA/Human-tc/JPN/AU-l/1982/G3P3[9] | G3 | P[9] | I3 | R3 | C3 | M3 | A3 | N3 | T3 | E3 | H3 |
| Cattle | |||||||||||
| RVA/Cow-tc/USA/NCDV/1967/G6P6[1] | G6 | P[1] | I2 | R2 | C2 | M2 | A3 | N2 | T6 | E2 | H3 |
| RVA/Cow-wt/IND/RUBV3/200X/G3P[3] | G3 | P[3] | I2 | – | – | – | – | – | – | E2 | H3 |
| RVA/Cow-wt/KOR/K5/2005/G5P[7] | G5 | P[7] | I5 | R1 | C1 | M1 | A1 | N1 | T1 | E1 | H1 |
| RVA/Cow-tc/KOR/KJ44/200X/G5P[1] | G5 | P[1] | I1 | R1 | C1 | M2 | A1 | N1 | T1 | E1 | H1 |
| RVA/Cow-tc/KOR/KJ75/200X/G5P[5] | G5 | P[5] | I1 | R1 | C1 | M2 | A1 | N1 | T1 | E1 | H1 |
| RVA/Cow-tc/KOR/KJ9-1/200X/G6P[7] | G6 | P[7] | I2 | R2 | C1 | M2 | A1 | N2 | T1 | E2 | H1 |
| RVA/Cow-tc/KOR/KJ9-2/200X/G6P[7] | G6 | P[7] | I2 | R2 | C2 | M2 | A3 | N2 | T6 | E2 | H3 |
| RVA/Cow-tc/KOR/KJ25-1/200X/G8P[7] | G8 | P[7] | I5 | R1 | C1 | M2 | A1 | N1 | T1 | E1 | H1 |
| RVA/Cow-wt/IND/BRV-68/200X/G8P[14] | G8 | P[14] | I2 | – | – | – | – | – | – | E2 | – |
| RVA/Cow-wt/IND/RUBV81/200X/G10P[14] | G10 | P[14] | I2 | – | – | – | – | – | – | E2 | – |
| RVA/Cow-wt/ARG/B383/1998/G15P[11] | G15 | P[11] | I2 | R5 | C2 | M2 | A13 | N2 | T6 | E12 | H3 |
| RVA/Cow-wt/IND/RUBV117/200X/G15P[21] | G15 | P[21] | I2 | – | – | – | – | – | – | E2 | H3 |
| RVA/Cow-tc/DEU/993/83/1983/G18P[17] | G18 | P[17] | I4 | – | – | – | – | – | – | – | – |
| RVA/Cow-wt/JPN/Azuk-1/2006/G21P[29] | G21 | P[29] | I2 | R2 | C2 | M2 | A13 | N2 | T9 | E2 | H3 |
| RVA/Cow-wt/JPN/Dai-10/2007/G24P[33] | G24 | P[33] | I2 | R2 | C2 | M2 | A13 | N2 | T9 | E2 | H3 |
| Sheep/goat | |||||||||||
| RVA/Goat-tc/BGD/GO34/1999/G6P[1] | G6 | P[1] | I2 | R2 | C2 | M2 | A11 | N2 | T6 | E2 | H3 |
| RVA/Goat-tc/KOR/GRV/1998/G3P5[3] | G3 | P[3] | – | – | – | – | – | – | – | E3 | – |
| RVA/Sheep-tc/ESP/OVR762/2002/G8P[14] | G8 | P[14] | I2 | R2 | C2 | M2 | A11 | N2 | T6 | E2 | H3 |
| RVA/Sheep-tc/CHN/Lamb-NT/XXXX/G10P[15] | G10 | P[15] | I10 | R2 | C2 | M2 | A11 | N2 | T6 | E2 | H3 |
| Pigs | |||||||||||
| RVA/Pig-tc/USA/OSU/1975/G5P9[7] | G5 | P[7] | I5 | R1 | C1 | M1 | A1 | N1 | T1 | E1 | H1 |
| RVA/Pig-tc/MEX/YM/1983/G11P9[7] | G11 | P[7] | I5 | R1 | C1 | M1 | A8 | N1 | T1 | E1 | H1 |
| RVA/Pig-wt/CHN/sh0902/2007/G1P[7] | G1a | P[7] | – | – | – | – | – | – | – | E1 | – |
| RVA/Pig-wt/SVN/P21-5/2004/G1P[27] | G1 | P[27] | – | – | – | – | – | – | – | E9 | – |
| RVA/Pig-wt/THA/CMP034/2000/G2P[27] | G2 | P[27] | I5 | – | – | – | – | – | – | E9 | H1 |
| RVA/Pig-wt/CAN/AB82/2006/G2P[34] | G2b | P[34] | I5/14 | R1 | C1 | M1 | A8 | N1 | T7 | E9 | H1 |
| RVA/Pig-tc/VEN/A131/1998/G3P9[7] | G3 | P[7] | I5 | R1 | C2 | M1 | A1 | N1 | T1 | E1 | H1 |
| RVA/Pig-wt/THA/CMP29/08/2008/G3P[13] | G3 | P[13] | I5 | R1 | C1 | M1 | A8 | N1 | T1 | E1 | H1 |
| RVA/Pig-wt/THA/CMP48/08/2008/G3P[23] | G3 | P[23] | I5 | R1 | C1 | M1 | A8 | N1 | T1 | E1 | H1 |
| RVA/Pig-wt/IND/HP140/2002/G6P[13] | G6 | P[13] | I2 | – | – | – | – | – | – | E1 | H1 |
| RVA/Pig-wt/THA/CMP45/08/2008/G9P[23] | G9 | P[23] | I5 | R1 | C1 | M1 | A8 | N1 | T7 | E1 | H1 |
| RVA/Pig-wt/VEN/A253/1998/G11P9[7] | G11 | P[7] | R1 | C2 | M1 | A1 | N1 | T1 | E1 | H1 | R1 |
| RVA/Pig-wt/IND/RU172/2002/G12P[7] | G12 | P[7] | I5 | R1 | C1 | M1 | A1 | N1 | T1 | E1 | H1 |
| Horses | |||||||||||
| RVA/Horse-wt/IRL/03V04954/2003/G3P[12] | G3 | P[12] | I6 | R2 | C2 | M3 | A10 | N2 | T3 | E2 | H7 |
| RVA/Horse-wt/ARG/E403/2006/G14P[12] | G14 | P[12] | I2 | R2 | C2 | M3 | A10 | N2 | T3 | E12 | H7 |
| RVA/Horse-wt/ARG/E3198/2008/G3P[3] | G3 | P[3] | I3 | R3 | C3 | M3 | A9 | N3 | T3 | E3 | H6 |
| RVA/Horse-tc/JPN/HH-22/1989/G3P[12] | G3 | P[12] | I6 | R2 | C2 | M3 | A10 | N2 | T3 | E2 | H7 |
| RVA/Horse-tc/GBR/H-1/1975/G5P9[7] | G5 | P[7] | I5 | R1 | C1 | M1 | A8 | N1 | T1 | E1 | H1 |
| RVA/Horse-tc/JPN/OH-4/1982/G6P[5] | G6 | P[5] | I2 | R2 | C2 | M2 | A13 | N2 | T6 | E2 | H3 |
| RVA/Horse-tc/GBR/L338/1991/G13P[18] | G13 | P[18] | I6 | R9 | C9 | M6 | A6 | N9 | T12 | E14 | H11 |
| Cats | |||||||||||
| RVA/Cat-tc/AUS/Cat97/1984/G3P[3] | G3 | P[3] | I3 | R3 | C2 | M3 | A9 | N2 | T3 | E3 | H6 |
| RVA/Cat-wt/ITA/BA222/2005/G3P[9] | G3 | P[9] | I2 | R2 | C2 | M2 | A3 | N1 | T3 | E2 | H3 |
| RVA/Cat-tc/AUS/Cat2/1984/G3P[9] | G3 | P[9] | I3 | R3 | C2 | M3 | A3 | N1 | T6 | E3 | H3 |
| Birds | |||||||||||
| RVA/Turkey-tc/IRL/Ty-3/1979/G7P[17] | G7 | P[17] | I4 | – | – | – | – | – | – | E11 | – |
| RVA/Turkey-tc/IRL/Ty-1/1979/G17P[17] | G17 | P[17] | I4 | – | – | – | – | N4 | – | E4 | – |
| RVA/Pigeon-tc/JPN/PO-13/1983/G18P[17] | G18 | P[17] | I4 | R4 | C4 | M4 | A4 | N4 | T4 | E4 | H4 |
| RVA/Chicken-tc/DEU/02V0002G3/2002/G19P[30] | G19 | P[30] | I11 | R6 | C6 | M7 | A16 | N6 | T8 | E10 | H8 |
| RVA/Chicken-tc/DEU/06V0661/2006/G19P[31] | G19 | P[31] | I11 | – | – | – | – | – | – | – | H8 |
| RVA/Turkey-tc/DEU/03V0002E10/2003/G22P[39] | G22 | P[35] | I4 | R4 | C4 | M4 | A16 | N4 | T4 | E11 | H4 |
| RVA/Pheasant-tc/DEU/10V0112H5/2010/G23P[37] | G23 | P[37] | I4 | R4 | C4 | M4 | A16 | N10 | T4 | E4 | H4 |
| Exotic animals | |||||||||||
| Non-human primates | |||||||||||
| RVA/Simian-tc/ZAF/SA11-H96/1958/G3P5B[2] | G3 | P[2] | I2 | R2 | C5 | M5 | A5 | N5 | T5 | E2 | H5 |
| RVA/Simian-tc/ZAF/SA11-Both/1958/G3P5B[2] | G3 | P[2] | I2 | R2 | C5 | M5 | A5 | N2 | T5 | E2 | H5 |
| RVA/Simian-tc/ZAF/SA11-30/19/1958/G3P[1] | G3 | P[1] | I2 | R2 | C5 | M5 | A5 | N5 | T5 | E2 | H5 |
| RVA/Simian-tc/ZAF/SA11-5S/1958/G3P[1] | G3 | P[1] | I2 | R2 | C5 | M5 | A5 | N5 | T5 | E2 | H5 |
| RVA/Simian-tc/USA/RRV/1975/G3P[3] | G3 | P[3] | I2 | R2 | C3 | M3 | A9 | N2 | T3 | E3 | H6 |
| RVA/Macaque-tc/USA/YK-1/XXXX/G3P[3] | G3 | P[3] | – | – | – | – | – | – | – | E3 | – |
| RVA/Rhesus-tc/USA/TUCH/2002/G3P[24] | G3 | P[24] | I9 | R3 | C3 | M3 | A9 | N1 | T3 | E3 | H6 |
| RVA/Macaque-tc/PTRV/1990/G8P[1] | G8 | P[1] | I2 | R2 | C2 | M2 | A3 | N2 | T6 | E2 | H3 |
| Hoofed mammals | |||||||||||
| RVA/Antelope-wt/ZAF/RC-18/08/2008/G6P[14] | G6 | P[14] | I2 | R2 | C2 | M2 | A11 | N2 | T6 | E2 | H3 |
| RVA/Guanaco-wt/ARG/Rio_Negro/1998/G8P[1] | G8 | P[1] | I2 | R5 | C2 | M2 | A11 | N2 | T6 | E12 | H3 |
| RVA/Guanaco-wt/ARG/Chubut/1999/G8P[14] | G8 | P[14] | I2 | R5 | C2 | M2 | A3 | N2 | T6 | E12 | H3 |
| RVA/Vicuna-wt/ARG/C75/2010/G8P[14] | G8 | P[14] | I2 | R2 | C2 | M2 | A? | N2 | T6 | E3 | H? |
| Bats | |||||||||||
| RVA/Bat-tc/CHN/MSLH14/2012/G3P[3] | G3 | P[3] | I8 | R3 | C3 | M3 | A9 | N3 | T3 | E3 | H6 |
| RVA/Bat-tc/KEN/KE4852/07/2007/G25P[6] | G25 | P[6] | I15 | R8c | C8 | M? | A? | N8 | T11 | E2 | H10 |
| Rodents | |||||||||||
| RVA/Mouse-tc/USA/EB-Po/1982/G16P[16] | G16 | P[16] | I7 | R7 | C7 | M8 | A7 | N7 | T10 | E7 | H9 |
| RVA/Mouse-tc/USA/ETD_822/XXXX/G16P[16] | G16 | P[16] | I7 | R7 | C7 | M8 | A7 | N7 | T10 | E7 | H9 |
| RVA/Mouse-tc/BRA/EHP/1981/G16P[20] | G16 | P[20] | – | – | – | – | A7 | – | – | E7 | – |
| Rabbits | |||||||||||
| RVA/Rabbit-tc/CHN/N5/1992/G3P[14] | G3 | P[14] | I17 | R3 | C3 | M3 | A9 | N1 | T1 | E3 | H2 |
| RVA/Rabbit-tc/ITA/30/96/1996/G3P[14] | G3 | P[14] | I2 | R2 | C2 | M3 | A9 | N2 | T6 | E5 | H3 |
| Giant panda | |||||||||||
| RVA/Giant panda-tc/CHN/CH-1/2008/G1P[7] | G1a | P[7] | I5 | R1 | C1 | M1 | A1 | N1 | T1 | E1 | H1 |
The common bovine, canine/feline, equine, human and porcine RVA strains are italicised
aThe VP7 genes of strains sh0902 and CH-1 were most closely related to each other, and shared low nucleotide sequence identities (< 90 %) with those of other G1 strains [46, 148]
bThe porcine G2 VP7 gene was found to be genetically distinct from those of human G2 strains, and has been referred to as G2-like [16, 17, 61, 71, 75]
cOnly partial nucleotide sequence of the VP1 gene of strain KE4852/07 was obtained, which could not be assigned to any of the known VP1-R genotypes, and therefore, was tentatively designated as R8 [23]
“–” indicates that no nucleotide sequence data were available in the GenBank database