Figure 4.

Isomerization ratio of αA and αB crystallins. Different colors indicate the three structural regions of crystallin, with the N-terminal region in orange, the α-crystallin domain in blue, and the C-terminal extension in purple.⁴⁵ The black asterisks represent aspartic acid residues and the white asterisks represent serine residues. The stars (peptide 89–99 in αA and peptide 124–149 in αB) indicate regions where isomerization was detected but not quantified because of incomplete separation by HPLC.