Figure 3.

Networks of ERK substrates. Identified substrates were overlaid on interaction network from the STRING database ( http://string.embl.de). Only high-confidence interaction from experiments or databases were extracted for rat and complemented with human data set. Orange and red circles represent substrates identified and validated in the study, respectively. Major subnetworks concern splicing, nuclear trafficking and nucleoproteins, MAPK signaling, cell junctions and membrane signaling. Binary interactions were removed. Candidate ERK1/2 substrates show a high degree of connectivity (34/155 are interconnected).