Figure 3.

MC-deficient Cpa3-Cre; Mcl-1^fl/fl mice have reduced pathology after stroke. Quantification at 3 days after stroke of brain swelling (A) and infarct size (B) and numbers of microglia and lymphoid cells (C); granulocytes and macrophages (D); granulocytes, Act. macrophages, and macrophages (E) in Cpa3-Cre; Mcl-1^+/+ mice (which have normal numbers of MCs and basophils) and Cpa3Cre; Mcl-1^fl/fl mice (which have markedly reduced numbers of MCs and also reduced numbers of basophils). Data are expressed as means ± SEM. The number of mice in each group is indicated in each bar. ^∗P < 0.05. P = 0.07 for lymphoid cells (C) and P = 0.08 for granulocytes (E). Act., activated.