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. Author manuscript; available in PMC: 2015 Sep 1.
Published in final edited form as: Psychopharmacology (Berl). 2014 Jan 31;231(17):3293–3312. doi: 10.1007/s00213-014-3435-3

Figure 14.

Figure 14

Comparison of the protective efficacy of ent-PREGS, ent-DHEAS and their respective natural stereoisomers pre-injected 6 h (A, C) or 12 h (B, D) prior to Aβ25-35 peptide in mice: (A, B) Spontaneous alternation performances on day 7 and (C, D) passive avoidance response on days 8-9. Mice were cannulated and administered i.c.v. with distilled water (V) or ent-PREGS (ent-PS), PREGS, ent-DHEAS (ent-DS) or DHEAS (each at 0.5 nmol) either 6 h or 12 h before the Aβ25-35 peptide (9 nmol). The i.c.v. injection of ScAβ (9 nmol) was used as control. F(5,69) = 10.0, p < 0.0001, n = 11-12 per group, in (A); F(5,71) = 5.92, p < 0.0001, n = 12 per group, in (B); H = 27.9, p < 0.0001, n = 11-12, in (C); H = 24.3, p < 0.001, n = 12, in (D). ** p < 0.01 vs. the (ScAβ+V)-treated group; ## p < 0.01 vs. the (Aβ25-35+V)-treated group; Dunnett's test in (A, B), Dunn's test in (C, D).