Table 1.
Patient Characteristics
| Characteristic | Age | p value | ||
|---|---|---|---|---|
| <55 | ≥55 | |||
| Number | 1814 | 100 | ||
| Median Age at Entry (Range) | 30 (14–54) | 56 (55–65) | ||
| Group | MRC | 1204 (66%) | 20 (20%) | p<0.0001 |
| ECOG | 610 (34%) | 80 (80%) | ||
| Sex | Male | 1113 (61%) | 53 (53%) | p=0.1 |
| Female | 701 (39%) | 47 (47%) | ||
| Lineage | B | 1401 (77%) | 81 (81%) | p=0.2 B vs. T |
| T | 350 (19%) | 14 (14%) | ||
| Other/Unknown | 63 (3%) | 5 (5%) | ||
| Disease Bulk | CNS disease | 91 (5%) | 5 (5%) | p=1.0 |
| Lymph nodes enlarged | 554 (31%) | 17 (17%) | p=0.004 | |
| Splenomegaly | 527 (29%) | 16 (16%) | p=0.005 | |
| Hepatomegaly | 305 (17%) | 9 (9%) | p=0.04 | |
| Anterior mediastinal mass | 158 (9%) | 4 (4%) | p=0.1 | |
| Comorbidities | Creatinine raised | 141 (8%) | 3 (3%) | p=0.08 |
| Bilirubin raised | 246 (14%) | 11 (11%) | p=0.5 | |
| AST raised | 493 (27%) | 30 (30%) | p=0.5 | |
| Presenting WCC | <50 × 109 /L | 1334 (74%) | 78 (78%) | p=0.2 (excluding missing) |
| ≥50 × 109 /L | 468 (26%) | 20 (20%) | ||
| Unknown | 12 (<1%) | 2 (2%) | ||
|
Ph t(9;22)* All Patients |
Positive | 247 (14%) | 20 (20%) | p=0.07 Ph+ vs. Ph−/unknown |
| Negative | 1370 (76%) | 67 (67%) | ||
| Unknown | 197 (11%) | 13 (13%) | ||
|
Ph t(9;22)* Pre-Imatinib sub-study |
Positive | 246 (17%) | 20 (28%) | p=0.02 Ph+ vs. Ph−/unknown |
| Negative | 1064 (73%) | 44 (62%) | ||
| Unknown | 141 (10%) | 7 (10%) | ||
| Other cytogenetics* | t(8;14) | 18/1258 (1%) | 1/60 (2%) | p=0.8 |
| t(4;11) | 74/1327 (6%) | 3/60 (5%) | p=0.8 | |
| t(1;19) | 28/1214 (2%) | 2/59 (3%) | p=0.6 | |
| Complex | 58/1213 (5%) | 3/59 (5%) | p=0.9 | |
| HeH* | 130/1226 (11%) | 6/59 (10%) | p=0.9 | |
| HoTr* | 39/1224 (3%) | 3/59 (5%) | p=0.4 | |
| Cytogenetic risk group* | Standard | 811 (65%) | 35 (54%) | p=0.07 |
| High | 437 (35%) | 30 (46%) | ||
*
HeH:High hyperdiploidy (51–65 chromosomes), HoTr: Low hypodiploidy / near-triploidy, High risk cytogenetics: t(9;22)(q34;q11), t(4;11)(q21;q23), t(8;14)(q24;q32), low hypodiploidy / near-triploidy (HoTr) or complex karyotype.
Genetic results were a mixture of cytogenetic, FISH and PCR results. No genetic data was available in 87 cases in the younger age group and 7 in the older. In cases where molecular data only was available, it was not possible to investigate the complete set of so the numbers analysed differ between abnormalities.