Table 2.

Multivariable Models for ST2 and Risk for Long Term Outcomes

	All-Cause Death/Hospitalization			CV Death/HF Hospitalization			All-Cause Death			CV Death			HF Hospitalization
	HR	95% CI	P-value	HR	95% CI	P-value	HR	95% CI	P-value	HR	95% CI	P-value	HR	95% CI	P-value
ST2 univariable	1.48	1.32–1.66	<0.0001	2.14	1.84–2.49	<0.0001	2.33	1.93–2.81	<0.0001	2.53	2.04–3.14	<0.0001	2.00	1.69–2.36	<0.0001
Demographics
+ age, sex, race	1.42	1.26–1.61	<0.0001	2.07	1.78–2.42	<0.0001	1.99	1.63–2.43	<0.0001	2.30	1.82–2.90	<0.0001	1.98	1.67–2.34	<0.0001
+ age, sex, race, NT-proBNP	1.17	1.02–1.34	0.0210	1.47	1.22–1.77	<0.0001	1.52	1.20–1.93	0.0006	1.68	1.26–2.24	0.0004	1.44	1.18–1.77	0.0005
Final clinical model without CPX variables
+ age, sex, race	1.29	1.13–1.50	0.0003	1.68	1.40–2.02	<0.0001	1.74	1.40–2.16	<0.0001	1.98	1.50–2.60	<0.0001	1.52	1.25–1.86	<0.0001
+ age, sex, race, NT-proBNP	1.13	0.97–1.33	0.1213	1.37	1.11–1.69	0.0037	1.42	1.10–1.82	0.0067	1.60	1.15–2.21	0.0047	1.32	1.05–1.65	0.0174
Final clinical model with CPX variables
+ age, sex, race	1.21	1.05–1.40	0.0072	1.50	1.24–1.82	<0.0001	1.47	1.18–1.85	0.0008	1.70	1.27–2.27	0.0004	1.35	1.10–1.66	0.0047
+ age, sex, race, NT-proBNP	1.08	0.92–1.27	0.3605	1.32	1.06–1.63	0.0129	1.26	0.97–1.63	0.0877	1.54	1.10–2.14	0.0114	1.22	0.97–1.54	0.0967

HR = Hazard ratio, CI = confidence interval, NT-proBNP = amino-terminal-pro-b-type natriuretic peptide, CPX = cardiopulmonary exercise test