Table 3.

Image quality metrics of 6 patients with brain deficits on either RMCA or LMCA indicated by the rectangles in Fig. 9 and on the whole brain. Each section divided by a horizontal line is the metric values for one patient. The first row in each section is the results using Patlak model. The second row is these using the shd-Patlak model trained on cases with brain deficits in the BBBP maps. The third row is these using the shd-Patlak model trained on cased with normal brain BBBP maps. The best performance in the average value for each metric and region is highlighted with bold font. P1 is the p-value for comparison between Patlak and shd-Patlak trained on deficit cases. P2 is the p-value for the comparison between Patlak and shd-Patlak trained on normal cases. P3 is the p-value for the comparison between shd-Patlak model trained on the deficit cases and shd-Patlak trained on normal cases.

ID	Method	RMCA			LMCA			Brain
		LSNR	RMSE	SSIM	LSNR	RMSE	SSIM	LSNR	RMSE	SSIM
2	Patlak	1.21	0.20	0.52	1.18	0.20	0.51	0.88	0.17	0.58
	shd (defcit)	1.63	0.10	0.79	1.68	0.10	0.78	1.11	0.09	0.82
	shd (normal)	1.58	0.10	0.81	1.66	0.10	0.78	1.09	0.08	0.83
4	Patlak	1.27	1.16	0.40	1.30	1.18	0.38	0.87	0.97	0.52
	shd (defcit)	2.03	0.51	0.71	2.32	0.52	0.71	1.17	0.44	0.77
	shd (normal)	1.94	0.53	0.69	2.18	0.52	0.71	1.15	0.44	0.77
6	Patlak	1.19	0.74	0.55	1.24	0.76	0.54	0.82	0.62	0.63
	shd (defcit)	1.91	0.39	0.78	2.00	0.39	0.77	1.07	0.33	0.82
	shd (normal)	1.88	0.40	0.78	1.84	0.38	0.79	1.05	0.33	0.83
8	Patlak	1.59	0.91	0.39	1.38	0.88	0.37	1.01	0.77	0.48
	shd (defcit)	2.52	0.39	0.72	2.41	0.39	0.69	1.28	0.34	0.76
	shd (normal)	2.43	0.40	0.72	2.29	0.40	0.69	1.27	0.35	0.75
9	Patlak	1.35	0.91	0.48	1.22	0.86	0.46	0.81	0.71	0.61
	shd (defcit)	2.17	0.42	0.77	2.20	0.41	0.74	1.06	0.35	0.82
	shd (normal)	2.02	0.42	0.78	2.07	0.41	0.76	1.04	0.35	0.83
10	Patlak	1.62	1.11	0.49	1.49	1.11	0.49	1.01	0.94	0.59
	shd (defcit)	2.52	0.54	0.75	2.10	0.53	0.76	1.21	0.47	0.81
	shd (normal)	2.49	0.55	0.74	2.07	0.55	0.75	1.20	0.48	0.80
Mean	Patlak	1.37	0.84	0.47	1.30	0.83	0.46	0.90	0.70	0.57
	shd (defcit)	2.13	0.39	0.75	2.12	0.37	0.74	1.15	0.34	0.80
	shd (normal)	2.06	0.40	0.75	2.02	0.39	0.75	1.13	0.34	0.80
Std	Patlak	0.19	0.35	0.06	0.12	0.35	0.07	0.09	0.29	0.06
	shd (defcit)	0.35	0.16	0.03	0.26	0.16	0.04	0.09	0.13	0.03
	shd (normal)	0.35	0.16	0.04	0.23	0.16	0.04	0.09	0.14	0.03
P	P1	<0.001	<0.01	<0.001	<0.001	<0.01	<0.001	<0.001	<0.01	<0.001
	P2	<0.001	<0.01	<0.001	<0.001	<0.01	<0.001	<0.001	<0.01	<0.001
	P3	0.01	0.04	1.00	0.01	0.47	0.36	<0.001	0.61	0.69