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. 2014 Oct 7;9(10):e108505. doi: 10.1371/journal.pone.0108505

Figure 4. RGS5 expression is regulated by profibrotic cytokines in concert with ETB.

Figure 4

LX2 HSCs were treated with TNFα (5 ng/ml), TGFβ (5 ng/ml), PDGF-BB (10 µM), and ET-1 (100 nm) for 24 hr. RNA was collected for qPCR analysis of RGS5 and ETB expression. Both RGS5 and ETB are up-regulated by TNFα stimulation and down-regulated by TGFβ stimulation. RGS5 and ETB expression are correlated, responding similarly to the same stimuli. n = 3, error bars  = SEM, * = p<0.05.