Figure 6. Rgs5^LacZ/LacZ mice have disrupted hepatocyte morphology after injury.

Acute CCl₄-induced injury in Rgs5^+/+ mice (A–C) and Rgs5^LacZ/LacZ (D–F). A,D. Uninjured mice are histologically normal. B,E At 48 hr post CCl₄ injection, foci of necrosis are visible central veins in both Rgs5^+/+ and Rgs5^LacZ/LacZ mice. C,F. At 96 hr post injury, clearance of necrotic hepatocytes is underway and infiltrating cells remain at the site of injury. F. In Rgs5^LacZ/LacZ mice, hepatocytes throughout the liver have cleared cytoplasm. Scale bars are 100 µm.