Table 3. Association between PNPLA3 and risk of NAFLD based on multiple logistic regression analysis, adjusted for confounding factors.
| Variable | Uygur | Han | ||||
| OR | 95% CI | p-value | OR | 95% CI | p-value | |
| Sex | ||||||
| female | 1 | - | - | - | ||
| male | 3.22 | 1.54–6.73 | 0.002 | - | - | - |
| Age (years) | 0.002 | 0.033 | ||||
| ≤40 | 1 | - | - | - | - | |
| 41–59 | 0.25 | 0.11–0.55 | 0.001 | 0.79 | 0.43–1.45 | 0.454 |
| ≥60 | 0.2 | 0.04–1.12 | 0.067 | 0.23 | 0.07–0.69 | 0.009 |
| BMI | ||||||
| <25 kg/m2 | 1 | - | ||||
| ≥25 kg/m2 | 15.46 | 5.70–41.93 | 0 | 11.25 | 6.01–21.06 | < 0.000 |
| BP Stage | ||||||
| <140/90 mmHg | 1 | - | 1 | - | ||
| ≥140/90 mmHg | 2.44 | 1.21–4.92 | 0.012 | 1.96 | 1.05–3.68 | 0.036 |
| Glucose Stage | ||||||
| <6.1 mmol/L | 1 | - | - | - | ||
| ≥6.1 mmol/L | 7.48 | 1.49–37.49 | 0.014 | - | - | - |
| TG Stage | ||||||
| <1.7 mmol/L | 1 | - | 1 | - | ||
| ≥1.7 mmol/L | 4.73 | 2.26–9.92 | <0.000 | 4.13 | 2.25–7.58 | < 0.000 |
| Family History ofHypertension | ||||||
| No | 1 | - | - | - | ||
| Yes | 0.46 | 0.23–0.89 | 0.022 | - | - | - |
| rs738409 | 0.012 | 0.005 | ||||
| CC genotype | 1 | - | 1 | - | - | |
| GC genotype | 1.08 | 0.56–2.12 | 0.812 | 1.42 | 0.77–2.64 | 0.266 |
| GG genotype | 4.29 | 1.60–11.48 | 0.004* | 5.22 | 1.94–14.04 | 0.001* |
*p<0.05 indicates statistical significance.