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. Author manuscript; available in PMC: 2014 Nov 1.
Published in final edited form as: Mutat Res. 2013 Oct 8;0:15–23. doi: 10.1016/j.mrfmmm.2013.09.004

Figure 5.

Figure 5

The kinetics of DNA Repair excision activity of pBSII DNA containing both Acr- and HNE-dG adducts. The dual-modified plasmid DNA containing 4.5 Acr-dG/103 dG and 2.5 HNE-dG/103 dG was incubated with HT-29 cell nuclear extracts as described in section 2.5. The LC-MS/MS method was used to determine (A) Repair kinetics of HNE–dG in dual-modified vs. single-modified plasmid DNA and (B) Repair kinetics of Acr-dG in dual-modified vs. single-modified plasmid DNA. The data are the mean value derived from three independent experiments and presented with standard errors. A, P>0.05 and B, P<0.01 by Student’s t test (one-tailed).