Table 3.
Relationship between acute graft-versus-host disease and outcome in patients who achieved remission on protocol and went on to receive an HSCT in first remission
| GVHD |
OR* (95% CI), log rank P | ||
|---|---|---|---|
| Yes | No | ||
| No. of patients | 44 | 20 | |
| Relapses | 10 | 12 | |
| Deaths in remission (TRM) | 17 | 3 | |
| Any event | 27 | 15 | |
| Actuarial risk of relapse at 5 y (95% CI) | 32% (15%-49%) | 65% (43%-87%) | 3.63 (1.44-9.18), .01† |
| Actuarial risk of TRM at 5 y (95% CI) | 43% (27%-59%) | 14% (0%-32%) | 0.51 (0.19-1.34), > 0.1 |
| Actuarial risk of any event at 5 y (95% CI) | 62% (47%-76%) | 70% (50%-90%) | 1.42 (0.73-2.78), > 0.1 |
OR indicates odds ratio; and CI, confidence interval.
*
OR greater than 1 indicates an increased risk of the observed event in the absence of GVHD.
†
Statistically significant P values.