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Treatment of calcium dependent desmosomes (A) with LCM causes loss of intercellular adhesion and formation of half desmosomes (B). These are internalised by a mechanism dependent on cPKC and actin filaments (C). Once internalised, desmosomal halves are transported in a microtubule/kinesin dependent manner to the centrosome and degraded by lysosomes and proteasomes (D).
