Figure 5. Association of NKG2D with mesenchymal and hybrid EMT phenotypes in orthotopic xenograft-derived tumors.

Cell suspensions from tumors derived from immunodeficient mice orthotopically xenografted with breast cancer SUM149PT–TF cells (upper bar graph) are strongly skewed towards hybrid E-cadherin⁺/N-cadherin⁺ and further transitioned E-cadherin⁻/N-cadherin⁺ phenotypes in comparison to control mock-transfected SUM149PT cell tumors (lower bar graph). E⁺N^–, E⁺N⁺, and E^–N⁺ refer to E-cadherin and N-cadherin status; mID, mouse identification number.