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. 2014 Oct 7;9(10):e109811. doi: 10.1371/journal.pone.0109811

Figure 8. Simultaneous effects of 17-AAG treatment and TAZ knockdown or YAP/TAZ double knockdown.

Figure 8

(A) Treatment of TAZ knockdown cells with 17-AAG facilitated significant increases in cell alignment only when cultured on 400 nm surfaces and remained unaltered when compared with control cells on other pitches. (B) Double knockdown of YAP/TAZ eliminates contact guidance in corneal epithelial cells. However, treatment of double knockdown cells with 17-AAG resulted in a significant increase in cell alignment only on 400 nm pitch. Statistical comparisons were performed using Kruskal-Wallis pairwise multiple comparison, *p<0.05, **p<0.01, ***p<0.001 compared with planar and ##p<0.01, ###p<0.001 compared with control cells.