Table 1.
Demographic and Clinical data by group (control, pHD and mHD). pHD group were divided into Far from onset and Near onset based on estimated onset
| Control | Pre-manifest HD (pHD) | Pre-manifest HD Far | Pre-manifest HD Near | Manifest HD (mHD) | |
|---|---|---|---|---|---|
| Number of subjects | 21 | 20 | 10 | 10 | 19 |
| Gender, F/M | 16/5 | 11/9 | 6/4 | 5/5 | 7/12 |
| Age, years (range) | 42.45 (31–54) | 41.75 (30–52) | 41.56 (30–52) | 42.3 (32–51) | 44 (30–58) |
| Years of Education | 19.19** | 16.32 | 15.44 | 17.1 | 15.78 |
| Music training (Number of subjects) | 4 | 3 | 2 | 1 | 2 |
| Probability of Diagnosis (range) | N/A | 0.31*** (0.07 – 0.74) | 0.15 (0.07 – 0.27) | 0.47 (0.28 – 0.74) | 1.00 |
| Estimated Onset (range) | N/A | 9.13 (3.2–15.5) | 12.7 (9.8–15.5) | 6.12 (3.2–8.7) | N/A |
| UHDRS motor score (SD) | N/A | 9.35 (7.4)* | 5.6 (4.1) | 13.1 (8.2) | 24.89 (10.7) |
| SDMT (SD) | N/A | 53.11 (10.5) | 57.63 (7.4) | 49.5 (11.58) | 29.63 (7.7) |
| UHDRS TFC (SD) | N/A | 13.0 (0) | 11.0 (2.52) | ||
| UHDRS IS (SD) | N/A | 95 (7.07) | 91.5 (8.8) |
UHDRS= Unified Huntington’s disease rating scale; SDMT= Symbol digit modality test; TFC= Total functional capacity scale; IS= Independence scale;
*
= p<0.05;
**
= p<0.01;
***
p<0.0001