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. Author manuscript; available in PMC: 2015 Oct 15.
Published in final edited form as: Transplantation. 2014 Oct 15;98(7):721–728. doi: 10.1097/TP.0000000000000316

Figure 1. Activation of Nrf2 promotes Akt/Foxo1 signaling, and ameliorates liver IRI (6h of reperfusion after 90min of warm ischemia).

Figure 1

(A) Western-assisted expression of Nrf2, HO-1, phosphorylated Stat3 (p-Stat3), p-Akt, and Foxo1 in CoPP-preconditioned WT, Nrf2-deficient and CoPP-preconditioned Nrf2-deficient livers. β-actin served as an internal control. Data representative of three experiments. (B) The hepatocellular function in distict animal groups evaluated by sALT (IU/L) levels. Mean±SD; n=4–6 mice/group. *p<0.01, **p<0.005. (C) Representative H&E staining (magnification ×100) of IR-stressed livers. (a) WT; (b) WT+CoPP; (c) Nrf2 KO; (d) Nrf2 KO+CoPP; Mean±SD; n=4–6 mice/group.

Symbols used: sham ( Inline graphic ); WT ( Inline graphic ); WT+CoPP ( Inline graphic ); Nrf2 KO ( Inline graphic ); Nrf2 KO+CoPP ( Inline graphic ).