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Dose-response relationship of ISF PO2 normalized to baseline values. The baseline ISF PO2 values for HBOC-201 (N = 16 sites), MP50 (N = 21 sites), LP50 (N = 25 sites), and HSA group (N = 17 sites) were 56 ± 3, 53 ± 2, 65 ± 2 and 54 ± 2 mmHg, respectively. * signifies a statistically significant difference (p < 0.05) between that value and the baseline (BL) for that group. † signifies a statistical significance (p < 0.05) compared to LP50A at the applied dose.
