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. Author manuscript; available in PMC: 2015 Nov 1.
Published in final edited form as: Neuropharmacology. 2014 Jul 15;86:161–173. doi: 10.1016/j.neuropharm.2014.07.006

Figure 3. Long-term exposure to THC in adolescence suppresses oscillations in vitro in adult mPFC and via CB1Rs in SCx.

Figure 3

(A) Experimental time course. Animals were injected with the CB1R/CB2R agonist THC (5 mg/kg) or vehicle + the CB1R antagonist AM251 (0.3 or 0.5 mg/kg) in adolescence (P35–P55) once daily for 20 days. LFPs were recorded in vitro in slices of adult mPFC (B,C) or SCx (D–G). (B, C) Cumulative probability distributions of normalized oscillation power plotted on a log scale from LFPs recorded in mPFC of adult mice treated with vehicle (solid line) or (B) THC (dashed line) or (C) AM251 (dashed line) from P35–P55. KS tests compared the effect of adolescent cannabinoid treatment on normalized oscillation power. (D,E) Plots as in (B,C) of LFPs from adult SCx. (F,G) Plots as in (D,E), except normalized power was compared between animals treated with THC or AM251 + THC [0.3 mg/kg AM251 in (F); 0.5 mg/kg AM251 in (G)], and between vehicle and AM251 + THC with KS tests.