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. Author manuscript; available in PMC: 2015 Nov 1.
Published in final edited form as: Neuropharmacology. 2014 Jul 15;86:161–173. doi: 10.1016/j.neuropharm.2014.07.006

Table 3. Summary of statistical analysis of long-term adolescent (P35–P55) cannabinoid effects on normalized oscillation power in adult SCx.

Cannabinoid effects were compared between treatment conditions with KS tests. Percentages reported are the median normalized LFP power in the treatment after “vs” relative to the median normalized LFP power in the treatment before “vs” in the statistical comparison.

Long-Term Adolescent Cannabinoid Treatment SCx
Adolescent THC Treatment
Vehicle (n = 61 slices/24 mice) vs. THC (5 mg/kg) (n = 24 slices/7 mice)
p = 0.006, 66%
Adolescent AM251 Treatment
Vehicle (n = 61 slices/24 mice) vs. AM251 (0.3 mg/kg) (n = 10 slices/4 mice)
Vehicle (n = 61 slices/24 mice) vs. AM251 (0.5 mg/kg) (n = 12 slices/4 mice)
Vehicle (n = 61 slices/24 mice) vs. AM251 (1.0 mg/kg) (n = 8 slices/3 mice)
p = 0.068
p = 0.519
p< 0.010, 59%
Adolescent THC + AM251 Treatment
THC (5 mg/kg) {n = 24 slices/7 mice) vs. + AM251 (0.3 mg/kg) + THC (5 mg/kg) (n= 12 slices/4 mice)
Vehicle (n = 61 slices/24 mice) vs. + AM251 (0.3 mg/kg) + THC(5 mg/kg) (n = 12 slices/4 mice)
p = 0.004, 160%
p = 0.519
Adolescent THC + AM251 Treatment
THC (5 mg/kg) (n = 24 slices/7 mice) vs. + AM251 (0.5 mg/kg) +THC (5 mg/kg) (n= 12 slices/4 mice)
Vehicle (n = 61 slices/24 mice) vs. + AM251 (0.5 mg/kg) + THC(5 mg/kg) (n = 12 slices/4 mice)
p = 0.973
p = 0.144
Adolescent WIN Treatment
Vehicle (n = 61 slices/24 mice) vs. WIN (1 mg/kg) (n = 55 slices/21 mice)
p = 0.003, 74%
Adolescent AM4113 Treatment
Vehicle (n = 61 slices/24 mice) vs. AM4113 (1 mg/kg) (n = 22 slices/8 mice)
p = 0.621
Adolescent AM4113 + WIN Treatment
WIN (1 mg/kg) (n = 55 slices/21 mice) vs. AM4113 (1 mg/kg) + WIN (1 mg/kg) (n = 20 slices/7 mice)
Vehicle (n = 61 slices/24 mice) vs. AM4113(1 mg/kg) + WIN (1 mg/kg) (n = 20 slices/7 mice)
p = 0.021, 63%
p< 0.001, 46%
Adolescent AM630 Treatment
Vehicle (n = 61 slices/24 mice) vs. AM630 (1 mg/kg) (n = 19 slices/6 mice)
p = 0.009, 67%
Adolescent WIN-3 Treatment
Vehicle (n = 61 slices/24 mice) vs. WIN-3 (1 mg/kg) (n = 21 slices/7 mice)
p = 0.312