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. Author manuscript; available in PMC: 2015 Oct 30.
Published in final edited form as: Eur J Med Chem. 2014 Sep 6;86:528–541. doi: 10.1016/j.ejmech.2014.09.009

Figure 3.

Figure 3

In vitro HDAC inhibitory activity – Recombinant HDAC1 and HDAC6 were incubated with and without analogues at varying concentrations. Reactions were carried out for 1 hour at a concentration of 0–1 μM (for HDAC1) and 0–5 μM (for HDAC6) for all analogues. Analogues 16b and 16c showed the greatest similarity to largazole in its inhibition of HDAC1 and HDAC6. However, none of the compounds showed more than a 50% inhibition of HDAC6 activity, except at the highest concentration of 5 μM.