Table 2. Distribution of drug resistance patterns across the strata of socio-demographics, patient type, X-ray features and microscopic findings among PTB patients in tertiary care hospitals of Kolkata, India, 2010–2013 (N = 350).
| Susceptible | Single drug resistance | Non-MDR two drug resistance | Multi-drug resistance (MDR) | ||||||
| Continuous Variables | n | Mean (95% CI) | n | Mean (95% CI) | n | Mean (95% CI) | n | Mean (95% CI) | |
| Body mass index (kg/m2) | 63 | 19.99(19.63–20.35) | 42 | 19.74(19.25–20.22) | 202 | 18.99(18.78–19.20) | 43 | 18.87(18.37–19.36) | |
| Blood hemoglobin level (gm/dl) | 63 | 10.40(9.98–10.81) | 42 | 10.43(9.89–10.97) | 202 | 10.85(10.64–11.06) | 43 | 10.58(10.12–11.05) | |
| Categorical variables | Susceptible | Single drug resistant | Non-MDR two drug resistant | MDR | |||||
| Variables | Categories | n | Percentage (95% CI) | n | Percentage (95% CI) | n | Percentage (95% CI) | n | Percentage (95% CI) |
| Gender | Male | 44 | 69.84(58.19–81.49) | 31 | 73.81(59.94–87.68) | 143 | 70.80(64.47–77.12) | 32 | 74.42(60.83–88.01) |
| Female | 19 | 30.16(18.51–41.81) | 11 | 26.19(12.32–40.06) | 59 | 29.21(22.88–35.53) | 11 | 25.58(11.99–39.16) | |
| Age | <20 Yrs | 15 | 23.81(12.99–34.62) | 6 | 14.29(3.25–25.32) | 23 | 11.39(6.97–15.8) | 4 | 9.30(0.26–18.35) |
| 20–45 Yrs | 44 | 69.84(58.19–81.49) | 28 | 66.67(51.80–81.53) | 150 | 74.26(68.18–80.34) | 31 | 72.09(58.12–86.06) | |
| >45 Yrs | 4 | 6.35(0.15–12.54) | 8 | 19.05(6.66–31.43) | 29 | 14.36(9.48–19.23) | 8 | 18.60(6.49–30.72) | |
| Marital Status | Married | 45 | 71.43(59.96–82.90) | 33 | 78.57(65.63–91.51) | 162 | 80.20(74.66–85.74) | 35 | 81.40(69.28–93.51) |
| Unmarried | 18 | 28.57(17.10–40.04) | 9 | 21.43(8.49–34.37) | 40 | 19.80(14.26–25.34) | 8 | 18.60(6.49–30.72) | |
| Socio-economic status | LIG | 52 | 82.54(72.90–92.18) | 35 | 83.33(71.58–95.09) | 179 | 88.61(84.20–93.03) | 37 | 86.05(75.26–96.84) |
| MIG | 11 | 17.46(7.82–27.09) | 6 | 14.29(3.25–25.32) | 22 | 10.89(6.56–15.22) | 6 | 13.95(3.16–24.74) | |
| HIG | – | – | 1 | 2.381(0–7.19) | 1 | 0.50(0–1.47) | – | – | |
| Resident of | North 24 Parganas | 2 | 3.17(0.00–7.63) | 4 | 9.52(0.27–18.78) | 7 | 3.47(0.92–6.00) | – | – |
| South 24 Parganas | 5 | 7.94(1.07–14.80) | 9 | 21.43(8.49–34.37) | 37 | 18.32(12.93–23.70) | 5 | 11.63(1.65–21.61) | |
| Kolkata | 56 | 88.89(80.91–96.87) | 29 | 69.05(54.47–83.63) | 158 | 78.22(72.48–83.96) | 38 | 88.37(78.39–98.35) | |
| Patient type | New Infection | 44 | 69.84(58.19–81.49) | 23 | 54.76(39.06–70.46) | 36 | 17.82(12.50–23.14) | 7 | 16.28(4.78–27.78) |
| Relapsed | 13 | 20.63(10.36–30.91) | 15 | 35.71(20.60–50.83) | 106 | 52.48(45.53–59.42) | 20 | 46.51(30.98–62.04) | |
| Defaulter | 5 | 7.94(1.07–14.80) | 3 | 7.14(0–15.27) | 38 | 18.81(13.38–24.25) | 8 | 18.60(6.49–30.72) | |
| Treatment failure | 1 | 1.59(0.00–4.76) | 1 | 2.38(0–7.19) | 22 | 10.89(6.56–15.22) | 8 | 18.60(6.49–30.72) | |
| Sputum smear grade | Scanty | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
| Single positive | 34 | 53.97(41.31–66.62) | 12 | 28.57(14.32–42.82) | 99 | 49.00(42.06–55.96) | 20 | 46.51(30.98–62.04) | |
| Double positive | 27 | 42.86(30.29–55.42) | 28 | 66.67(51.80–81.53) | 81 | 40.10(33.28–46.91) | 21 | 48.84(33.27–64.40) | |
| Triple positive | 2 | 3.17(0–7.63) | 2 | 4.76(0–11.48) | 22 | 10.89(6.56–15.22) | 2 | 4.65(0–11.21) | |
| X- Ray Findings | Minimal | 21 | 33.33(21.37–45.30) | 11 | 26.19(12.32–40.06) | 76 | 37.62(30.89–44.36) | 18 | 41.86(26.50–57.22) |
| Moderately advanced | 27 | 42.86(30.30–55.42) | 18 | 42.86(27.25–58.47) | 74 | 36.63(29.93–43.33) | 13 | 30.23(15.93–44.53) | |
| Far advanced | 12 | 19.05(9.08–29.02) | 9 | 21.43(8.49–34.37) | 29 | 14.36(9.48–19.23) | 10 | 23.26(10.10–36.41) | |
| Cavity | 3 | 4.76(0–10.17) | 4 | 9.52(0.27–18.78) | 23 | 11.39(6.97–15.80) | 2 | 4.65(0–11.21) | |
N = Total number of subjects in the study; n = Number of subjects in different categories.
CI = Confidence interval; LIG = Low-income group; MIG = Middle-income group; HIG = High-income group.