Fig. 3.

CatG deficiency attenuates early atherogenesis but aggravates later lesions. Atherosclerotic lesion areas in Ldlr^−/−Ctsg^−/− mice and Ldlr^−/−Ctsg^+/+ mice fed a Western diet for 3 months and 6 months. A. Thoracic-abdominal atherosclerotic lesion oil-red O-positive areas. Representative thoracic-abdominal aortas from the 3-month time point are shown on the left. B. Aortic arch intima areas from the perpendicular line between the left edge of the brachiocephalic artery and the ascending aorta to 3 mm towards the descending aorta as indicated by dotted lines (right two panels). Brachiocephalic artery, left common carotid artery, and left subclavian artery are also indicated in the representative aortic arches at the right panels. Data are mean ± SE. Number of mice per experimental group is indicated in each bar.