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. Author manuscript; available in PMC: 2015 Nov 1.
Published in final edited form as: Neuropharmacology. 2014 Aug 13;86:273–281. doi: 10.1016/j.neuropharm.2014.08.002

Figure 5.

Figure 5

Effects of pretreatment with low ketamine plus APV on synaptic responses and LTP. A. Unlike low ketamine alone, administration of 10 µM ketamine plus 5 µM D-APV for 30 min had no acute effect on either dendritic (circles) or somatic (squares) EPSPs. Traces show representative EPSPs and PSs recorded before (thin lines) and 60 min after (thick lines) drug washout. B. In slices pretreated with 10 µM ketamine plus 5 µM D-APV for 30 min followed by 2–4 hour drug washout, a single HFS (arrow) successfully induced LTP. Traces depict representative waveforms during the baseline period (thin) and 60 min following HFS (thick). Calibration: 1 mV, 5 msec.