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. 2014 Oct;184(10):2662–2670. doi: 10.1016/j.ajpath.2014.06.016

Figure 5.

Figure 5

Distribution of loss in the subbasal nerve plexus (SBNP). Representative 20× images of neuronal βIII tubulin–stained nerves of the full SBNP in control (A) and 18-week streptozotocin-treated (B) corneas. Note both diffuse nerve loss with patchy focal areas of dropout. B: Arrow indicates the damage at the area of the whorl. C and D: Three-dimensional surface rendering of the SBNP and terminal epithelial nerves (TEN) in normal (C) and diabetic (D) corneas. Three-dimensional nerve modeling and segmentation using Imaris Filament. E and F: The SBNP is shown in red and TENs are shown in blue. Normal SBNP and TENs (E), diabetic SBNP and TENs (F). Scale bars: 70 μm (B);10 μm (C and D).