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General roles of proteolytic enzymes in cancers
| Degradation or disruption of basement membrane and extracellular matrix |
| Produce components which allow the in situ cancer cells to disseminate to distant organ |
| Formation of a complex microenvironment that promotes malignant transformation |
| Activation of growth factors, adhesion molecules |
| Suppression of tumor cell apoptosis |
| Destruction of chemokine gradients |
| Modulation of antitumor immune reactions |
| Dual and complex role in angiogenesis |
