Table 3.
Etiology of the 8080 enrolled liver cirrhosis patients n (%)
| Etiology | Total | Male | Female | P value |
| (n = 8080) | (n = 6719) | (n = 1361) | ||
| Viral hepatitis | 6514 (80.62) | 5489 (81.69) | 1025 (75.31) | < 0.001 |
| HBV | 6239 (77.22) | 5316 (79.12) | 923 (67.82) | |
| HCV | 226 (2.80) | 135 (2.01) | 91 (6.69) | |
| HBV + HDV | 2 (0.02) | 2 (0.03) | 0 (0.00) | |
| HBV + HCV | 47 (0.58) | 36 (0.54) | 11 (0.81) | |
| Alcohol | 459 (5.68) | 451 (6.71) | 8 (0.59) | < 0.001 |
| Autoimmune | 163 (2.03) | 30 (0.43) | 133 (9.77) | < 0.001 |
| AIH | 54 (0.67) | 13 (0.19) | 41 (3.01) | |
| PBC | 87 (1.08) | 15 (0.22) | 72 (5.29) | |
| AIH + PBC | 19 (0.24) | 1 (0.01) | 18 (1.32) | |
| PSC | 3 (0.04) | 1 (0.01) | 2 (0.15) | |
| Secondary biliary | 38 (0.47) | 22 (0.33) | 16 (1.18) | < 0.001 |
| Metabolic diseases | 114 (1.40) | 73 (1.09) | 41 (3.02) | < 0.001 |
| WD | 106 (1.31) | 67 (1.00) | 39 (2.87) | |
| HH | 2 (0.02) | 2 (0.03) | 0 (0.00) | |
| NAFLD | 4 (0.05) | 2 (0.03) | 2 (0.15) | |
| Others | 2 (0.02) | 2 (0.03) | 0 (0.00) | |
| Drugs | 9 (0.11) | 6 (0.09) | 3 (0.22) | 0.186 |
| Vascular diseases | 46 (0.57) | 30 (0.44) | 16 (1.17) | 0.001 |
| BCS | 31 (0.38) | 21 (0.31) | 10 (0.73) | |
| Cardiac | 15 (0.19) | 9 (0.13) | 6 (0.44) | |
| Parasites | 33 (0.41) | 26 (0.39) | 7 (0.51) | 0.502 |
| IHS | 8 (0.10) | 7 (0.10) | 1 (0.07) | 1.000 |
| Mixed etiology | 400 (4.95) | 399 (5.93) | 1 (0.07) | < 0.001 |
| HBV + Alcohol | 389 (4.81) | 388 (5.77) | 1 (0.07) | |
| HBV + HCV + Alcohol | 11 (0.14) | 11 (0.16) | 0 (0.00) | |
| Other known etiology | 59 (0.73) | 51 (0.76) | 8 (0.58) | 0.499 |
| Cryptogenic cirrhosis | 237 (2.93) | 135 (2.01) | 102 (7.49) | < 0.001 |
The differences in gender proportion were determined using the χ2 test. HBV: Hepatitis B virus; HCV: Hepatitis C virus; HDV: Hepatitis D virus; AIH: Autoimmune hepatitis; PBC: Primary biliary cirrhosis; PSC: Primary sclerosing cholangitis; WD: Wilson’s disease; HH: Hereditary hemochromatosis; NAFLD: Non-alcoholic fatty liver disease; BCS: Budd-Chiari syndrome; IHS: Infantile hepatitis syndrome.