Table 5.
Etiologic analysis for the years 2001-2005 and the years 2006-2010 n (%)
| Etiology | 2001-2005 (n = 2907) | 2006-2010 (n = 5173) | χ2-value | P value | P-trend |
| Viral hepatitis | 2462 (84.7) | 4052 (78.3) | 48.22 | < 0.001 | < 0.001 |
| HBV | 2381 (81.9) | 3858 (74.6) | 56.78 | < 0.001 | < 0.001 |
| HCV | 67 (2.3) | 159 (3.1) | 4.05 | 0.044 | 0.263 |
| HBV + HCV | 12 (0.4) | 35 (0.7) | 2.24 | 0.135 | 0.267 |
| HBV + HDV | 2 (0.1) | 0 (0.0) | - | 0.129 | - |
| Alcohol | 155 (5.3) | 304 (5.9) | 1.031 | 0.31 | 0.919 |
| Autoimmune | 34 (1.2) | 129 (2.5) | 16.509 | < 0.001 | < 0.001 |
| Secondary biliary | 12 (0.4) | 26 (0.5) | 0.321 | 0.571 | 0.369 |
| Metabolic diseases | 32 (1.1) | 82 (1.6) | 3.139 | 0.076 | 0.07 |
| Drugs | 1 (0.0) | 8 (0.2) | 1.459 | 0.227 | 0.161 |
| Vascular diseases | 17 (0.6) | 29 (0.6) | 0.019 | 0.89 | 0.551 |
| Parasites | 14 (0.5) | 19 (0.4) | 0.598 | 0.439 | 0.154 |
| IHS | 2 (0.1) | 6 (0.1) | 0.078 | 0.78 | 0.696 |
| Mixed etiology | 87 (3.0) | 313 (6.1) | 36.984 | < 0.001 | < 0.001 |
| Other known etiology | 16 (0.5) | 43 (0.8) | 2.95 | 0.086 | 0.285 |
| Cryptogenic cirrhosis | 75 (2.6) | 162 (3.1) | 1.989 | 0.158 | 0.011 |
The P values were determined using the χ2 test by comparing the proportion of 2001-2005 with that of 2006-2010. The P-trend values were determined using ANOVA by comparing proportions of separated years and reflected the general trend of the etiology proportion in the 10 consecutive years.