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Optimal sofosbuvir containing regimens for chronic hepatitis C in early 2014. Sofosbuvir is administered as one tablet of 400 mg daily, ribavirin (RBV) is administered as weight-based dosing (total daily dose of 1000 or 1200 mg for patients with body weight ≤75 or >75 kg, respectively) and pegylated interferon-alfa-2a (pegIFN) is administered as subcutaneous injections of 180 μg once weekly
