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. 2014 Oct 8;34(41):13714–13724. doi: 10.1523/JNEUROSCI.5284-13.2014

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Copyright © 2014 the authors 0270-6474/14/3413714-11$15.00/0

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Figure 8. — Ethanol fails to increase the frequency of mIPSCs of CeA neurons in the presence of the selective BK channel blocker paxilline. A, Traces show mIPSCs recorded from a CeA neuron at a holding potential of −70 mV under control, during bath application of paxilline alone, and during coapplication of paxilline and ethanol. B, Paxilline alone shifts the cumulative distribution of the interevent intervals of mIPSC to the left (p < 0.001, K-S test). However, in the presence of paxilline, there is no change in the cumulative distribution of mIPSC frequency after bath application of ethanol (50 mm). C, The mean interevent interval of mIPSCs was significantly decreased following bath application of paxilline (*p < 0.05, paired t test), but ethanol no longer alters interevent intervals of mIPSCs in the presence of paxilline. D, There are no changes in the mean amplitude of mIPSCs after bath application of either paxilline or paxilline plus ethanol (p > 0.05).