Fig. 6.

The ShK domains from L. sigmodontis protein nLs_04059 and its orthologs in other filarial species have a distinct sequence signature. All ShK domains identified in the complete theoretical proteomes of L. sigmodontis, B. malayi, L. loa, W. bancrofti, O. ochengi, D. immitis, Acanthocheilonema viteae and Ascaris suum were extracted and aligned, and sequence logos derived from: (all ShK) all 531 domains, (04059) all domains from nLs_04059 and its orthologs, (1–6) the aligned orthologous domains 1 through 6 from nLs_04059 and its orthologs. No nLs_04059 ortholog was found in A. suum. As the nLs_04059 domains are relatively short, there are gaps in the sequence logos for the nLs_04059-derived domains. Numbering in all panels is based on the full ShK alignment.