Fig. 3.

Nucleotides metabolism influenced by bile stress in B. longum BBMN68. A, An operon composed of seven genes related with pyrimidine metabolism was repressed in the presence of bile. Changes in transcription level are represented as log2 intensity ratio values shown with the gene names. P and T indicate putative promoter and terminator, respectively. B, Schematic representation of the regulated pathways in nucleotides metabolism. Red and blue gene names indicated up- and down-regulation in the presence of bile.