Table 6. Associations of Selected Cancers with Exposure to Formaldehyde in Nested Case-control Analyses: Study of British Chemical Workers Exposed to Formaldehyde 1941-2012.
Cancer | Highest Level of Exposure | Cases | Controls | ORa | 95% CI |
---|---|---|---|---|---|
Upper airways | Background | 37 | 349 | ||
Low/Moderate | 33 | 384 | 0.84 | 0.49, 1.42 | |
High <1 year | 25 | 204 | 1.28 | 0.61, 2.67 | |
High ≥1 year | 20 | 201 | 1.03 | 0.48, 2.18 | |
Cancer of the Larynx | Background | 14 | 156 | ||
Low/Moderate | 17 | 177 | 1.20 | 0.53, 2.73 | |
High <1 year | 14 | 104 | 2.02 | 0.65, 6.27 | |
High ≥1 year | 8 | 93 | 1.30 | 0.39, 4.38 | |
Cancer of the Mouth | Background | 5 | 44 | ||
Low/Moderate | 3 | 44 | 0.59 | 0.12, 2.98 | |
High <1 year | 3 | 30 | 0.97 | 0.13, 7.47 | |
High ≥1 year | 3 | 22 | 1.38 | 0.17, 11.1 | |
Cancer of the Pharynx | Background | 10 | 89 | ||
Low/Moderate | 9 | 95 | 0.81 | 0.30, 2.22 | |
High <1 year | 3 | 35 | 0.63 | 0.13, 3.03 | |
High ≥1 year | 6 | 53 | 0.81 | 0.22, 3.05 | |
Cancer of the Tongue | Background | 5 | 34 | ||
Low/Moderate | 2 | 26 | 0.41 | 0.06, 2.58 | |
High <1 year | 1 | 19 | 0.19 | 0.01, 2.58 | |
High ≥1 year | 1 | 11 | 0.34 | 0.03, 4.35 | |
All Leukaemia | Background | 35 | 349 | ||
Low/Moderate | 39 | 350 | 1.08 | 0.64, 1.84 | |
High <1 year | 9 | 87 | 0.84 | 0.32, 2.20 | |
High ≥1 year | 9 | 128 | 0.59 | 0.23, 1.50 | |
Myeloid leukaemia | Background | 17 | 180 | ||
Low/Moderate | 19 | 186 | 1.10 | 0.51, 2.38 | |
High <1 year | 5 | 34 | 1.77 | 0.45, 7.03 | |
High ≥1 year | 4 | 50 | 0.96 | 0.24, 3.82 |
All risk estimates are relative to background exposure, and relate to exposure status five years before the case (for controls, the matched case) was first known to have been diagnosed.
CI = confidence interval OR = odds ratio