Figure 2. Correlation of Pgp activity and Pgp expression with postoperative outcome.

(A) Correlation of mean presurgical VPM-K₁ values in ipsilateral TL with surgery outcome rank in individual patients (see the methods section and figure e-1 for definition of surgery outcome rank order; r_s = Spearman rank correlation coefficient). (B) Correlation of percentage area of Pgp immunopositive labeling in the surgically resected hippocampus with surgery outcome rank in individual patients. (C) Mean percent change in VPM-K₁ values across all studied TL regions located ipsilateral to the seizure focus in postsurgery PET scan relative to presurgery PET scan. Patients 3 and 4 were both assigned rank 3, but the antiepileptic drug load of patient 3 was lower than that of patient 4. p = patient; Pgp = P-glycoprotein; TL = temporal lobe; VPM = (R)-[¹¹C]verapamil.