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. 2014 Oct 2;11:83. doi: 10.1186/s12977-014-0083-y

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© McCoy et al.; licensee BioMed Central Ltd. 2014

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Enhanced potency of full-length HCAb antibodies. (A) IC50μM for the mono-specific bivalent J3-Fc in comparison to J3 alone for the viruses listed. Very potent neutralisation (<0.001) is indicated in dark grey; potent neutralisation (0.001-0.01) in grey, intermediate neutralisation in light grey (0.01-0.5) and weak neutralisation in white (>0.5). IC50 values were generated from duplicate titrations of J3 and J3-Fc onto TZM-bl cells as described in the methods. (B) Fold increase in IC50 for J3-Fc relative to J3 for indicated viruses. The subtype/CRF of each individual virus is indicated on the X axis.