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. 2014 Sep 24;14:90. doi: 10.1186/s12935-014-0090-z

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© Albawardi et al.; licensee BioMed Central Ltd. 2014

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Breast lobular carcinoma in situ. (a-f) Histology and expression of caspase-3 by immunoperoxidase. (a-b) Untreated tumor demonstrating expanded acini by an in situ proliferation of uniform neoplastic cells, H&E at 10× and 40×, respectively. (d-e) Treated in situ carcinoma demonstrating fragmentation and degeneration of neoplastic cells (black arrow), H&E at 10× and 40×, respectively. (c and f) Untreated and treated tumor showed rare positivity (1%, black arrow) for caspase-3, immunoperoxidase (IP), 40×. (g) HPLC runs of intracellular caspase-3 activity in treated and untreated tumor. The AMC peak (retention time, ~4.8 min) in treated tumor was blocked by zVAD. (h) Cellular respiration, measured immediately on tumor arrival to the laboratory to affirm viability.