Table 1.

Summary of the included studies in the meta-analysis

Authors	Year	Duration	Group1/ Sample	Group 2/ Sample	Group 3/ Sample	Group 4/ Sample	Group 5/ Sample
Alvarez E et al. [10]	2011	6 weeks	Vortioxetine 5 mg/108	Vortioxetine 10 mg/100	Venlafaxine/113	Placebo/105	---
Baldwin DS et al. [14]	2012	8-week	Vortioxetine 2.5 mg/155	Vortioxetine 5 mg/155	Vortioxetine 10 mg/151	Duloxetine 60 mg/149	Placebo/145
Mahableshwarkar AR et al. [16]	2013	8 weeks	Vortioxetine 2.5 mg/146	Vortioxetine 5 mg/153	Duloxetine 60 mg/149	Placebo/149	---
Katona C et al. [11]	2012	8 weeks	Vortioxetine 5 mg/day/154	Duloxetine/147	Placebo/145	---	---
Jain R et al. [15]	2013	6 wks	Vortioxetine 5 mg/300	Placebo/300	---	---	---
Boulenger JP et al. [12]	2013	8 weeks	Vortioxetine 15 mg/151	Vortioxetine 20 mg/151	Duloxetine/147	Placebo/158	---
Henigsberg N et al. [13]	2012	8 wks	Vortioxetine 1 mg/124	Vortioxetine 5 mg/129	Vortioxetine 10 mg/122	Placebo/128	---